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Structural studies

  • Merret R, Martino L, Bousquet-Antonelli C, Fneich S, Descombin J, Billey E, Conte MR, Deragon JM.(2013). The association of a La module with the PABP-interacting motif PAM2 is a recurrent evolutionary process that led to the neofunctionalization of La-related proteins.┬áRNA 19, 36-50.
  • Martino, L., Pennell, S., Kelly, G., Bui, T.T.T, Kotik-Kogan, O., Smerdon, S.J., Drake, A.F., Curry, S. and Conte, M.R. (2011) Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein. Nuc. Acids Res.
  • Kotik-Kogan, O., Valentine, E.R., Sanfelice, D., Conte, M.R., and Curry, S. (2008). Structural analysis reveals conformational plasticity in the recognition of RNA 3′ ends by the human La protein. Structure 16, 852-862.
  • Sanfelice, D., Kelly, G., Curry, S., and Conte, M.R. (2008). NMR assignment of the N-terminal region of human La free and in complex with RNA. Biomol NMR Assign 2, 107-109.
  • Curry, S., and Conte, M.R. (2006). A terminal affair: 3′-end recognition by the human La protein. Trends Biochem Sci 31, 303-305.
  • Teplova, M., Yuan, Y.R., Phan, A.T., Malinina, L., Ilin, S., Teplov, A., and Patel, D.J. (2006). Structural basis for recognition and sequestration of UUU(OH) 3′ temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. Mol Cell 21, 75-85.
  • Alfano, C., Sanfelice, D., Babon, J., Kelly, G., Jacks, A., Curry, S., and Conte, M.R. (2004). Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein. Nat Struct Mol Biol 11, 323-329.
  • Dong, G., Chakshusmathi, G., Wolin, S.L., and Reinisch, K.M. (2004). Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch. Embo J 23, 1000-1007.
  • Alfano, C., Babon, J., Kelly, G., Curry, S., and Conte, M.R. (2003). Resonance assignment and secondary structure of an N-terminal fragment of the human La protein. J Biomol NMR 27, 93-94.
  • Jacks, A., Babon, J., Kelly, G., Manolaridis, I., Cary, P.D., Curry, S., and Conte, M.R. (2003). Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element. Structure 11, 833-843.
  • Jacks, A., Kelly, G., Curry, S., and Conte, M.R. (2002). Resonance assignment and secondary structure determination of a C-terminal fragment of the lupus autoantigen (La) protein containing a putative RNA recognition motif (RRM). J Biomol NMR 22, 387-388.