Phylogenetic relationship and structural organizations among LA-Motif containing proteins
(adapted from Bousquet-Antonelli and Deragon, (2009) RNA; Bayfield et al. (2010) BBA)
La-motif proteins fall into 5 evolutionary conserved families. Members of the same family share conserved domain organization. As for the genuine LA proteins, the LAM-RRM organization is conserved in every LA-Related Protein families. With the exception of the LARP7 family which has a canonical RRM1, other LARP families display a variant RRM named: RRM-L3a/3b; RRM-L4 and RRM-L5. In each family, the most commonly represented domain organization is highlighted (black arrow).

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